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Is Magnesium Glycinate just another passing health trend, or is there scientific merit to the claims?

Updated: Aug 10


Magnesium is a vital mineral that plays a critical role in over 600 biochemical processes within the body, including energy production, muscle and nerve function, and blood pressure regulation. Despite its importance, many people suffer from magnesium deficiency, which can lead to various health issues.


Lately, TikTok has been abuzz with talk about magnesium glycinate. But is this just another passing health trend, or is there scientific merit to the claims?


This blog explores the benefits of magnesium glycinate, its recommended dosage, possible side effects, and whether it is the best form of magnesium for sleep, anxiety and muscle repair.


What is Magnesium Glycinate?


Magnesium glycinate is a form of magnesium combined with the amino acid glycine. This pairing enhances absorption and bioavailability, allowing the body to utilize it more effectively. Often termed "chelated" magnesium, it is bound to another molecule to boost absorption.


Benefits of Magnesium Glycinate


While all forms of magnesium offer similar benefits, their effectiveness largely depends on how well they are absorbed. Magnesium glycinate is popular among health enthusiasts due to its superior absorption. Here are some key benefits:


Magnesium for Sleep


Magnesium is crucial in regulating the body's sleep-wake cycle by acting as a cofactor for ATP, the energy molecule, and signaling the rhythmic hormonal events that control the body clock. Research suggests that magnesium glycinate can improve sleep quality, prevent daytime sleepiness, and alleviate insomnia and restless leg syndrome. These benefits are further enhanced when combined with melatonin and vitamin B6.


Magnesium for Anxiety


Magnesium supplementation is known for its calming effects. It helps regulate neurotransmission by reducing the activity of calcium-dependent NMDA receptors, which, when overactivated, can lower GABA levels—a neurotransmitter essential for calming the nervous system and promoting sleep. Excessive NMDA receptor activation is linked to stress, depression, and anxiety, but magnesium can mitigate these effects by stabilizing GABA transmission.


Muscle Tissue Repair


Magnesium glycinate is also great for muscle tissue repair. It does this by aiding in protein synthesis, ensuring that damaged muscle fibers are repaired and replaced effectively. By replenishing magnesium levels, it supports the energy production required for muscle tissue repair. Magnesium glycinate also provides many anti-inflammatory benefits which help your muscles heal faster.


Magnesium also plays a role in energy production within muscle cells. It is vital for creating adenosine triphosphate (ATP), the primary energy molecule in the body. 


Magnesium's benefits are more indirect but equally significant in the context of joint health. As we saw, it contributes to bone health, which is essential for joint function. Magnesium helps regulate calcium transport, a crucial factor in maintaining bone density and preventing conditions like osteoporosis, which can indirectly affect joint health. 


Inflammation is another common driver of joint pain and can contribute to arthritis. By reducing inflammation, magnesium can help alleviate joint pain and improve joint mobility. This anti-inflammatory effect benefits the joints directly and helps reduce muscle stiffness and soreness, contributing to overall musculoskeletal health.



Other benefits of magnesium include:


  • Improved Digestion: Eases constipation and promotes healthy digestion.

  • Muscle Relaxation: Relieves muscle tension and cramps.

  • Migraine Relief: May reduce migraines in those with a deficiency.

  • Mood Enhancement: Eases tension, improves mood, and alleviates depressive symptoms.

  • PMS Relief: Reduces menstrual pain and cramps.

  • Bone Health: Essential for maintaining strong bones and preventing osteoporosis.

  • Heart Health: Lowers the risk of heart disease and regulates blood pressure.


Recommended Dosage of Magnesium Glycinate


For adults, the recommended daily intake of magnesium is between 310-420 mg, depending on age and gender. The dosage for magnesium glycinate may vary based on individual health needs and goals. It’s advisable to consult a healthcare provider to determine the appropriate dosage, especially for specific health conditions or if considering supplementation for children or teenagers.


Magnesium Deficiency: A Common Issue


It's estimated that up to 75% of Americans do not meet the recommended daily magnesium intake. Those at higher risk for deficiency include individuals with digestive disorders, chronic diarrhea, or those taking certain medications, such as proton pump inhibitors and diuretics.

Common signs of magnesium deficiency include muscle spasms, fatigue, anxiety, and trouble sleeping. Left unchecked, magnesium deficiency can lead to more severe conditions like osteoporosis and heart disease.


Top 10 Magnesium-Rich Foods


Incorporating the following foods into your diet can help boost your magnesium intake naturally:


  • Spinach

  • Pumpkin seeds

  • Almonds

  • Avocado

  • Dark chocolate

  • Bananas

  • Quinoa

  • Black beans

  • Tofu

  • Salmon


The Relationship Between Magnesium and Vitamin D


Magnesium and vitamin D work synergistically in the body, with magnesium playing a critical role in activating vitamin D. Without sufficient magnesium, vitamin D cannot be properly metabolized and used.

Together, magnesium and vitamin D support bone health by aiding calcium absorption and regulating calcium levels in the body. Vitamin D also supports the immune system, hormone regulation, brain health, skin health, and heart health.


Is Magnesium Glycinate the Best Form of Magnesium?


There are several forms of magnesium, including magnesium oxide, magnesium citrate, magnesium glycinate, magnesium malate, magnesium threonate, and magnesium taurate. Each form has unique benefits, but magnesium glycinate is often favored for its high bioavailability and low risk of digestive issues.

Although magnesium glycinate is not the highest in absorption among all forms, it is considered one of the best overall magnesium supplements. Magnesium citrate is preferred for its laxative effect, while magnesium threonate is better for brain health due to its ability to cross the blood-brain barrier.


Side Effects of Magnesium Glycinate


Magnesium is generally safe, with no established upper limit for daily intake. However, excessive consumption of magnesium glycinate may cause side effects such as diarrhea, nausea, stomach cramps, and upset stomach. Prolonged high doses could lead to issues with bone mineral density and electrolyte imbalances, potentially causing cardiac problems. It's important to consult a healthcare professional before starting any new supplement.


Is Daily Magnesium Glycinate Safe?


There is no evidence to suggest that daily magnesium supplementation is unsafe if taken within the recommended dosage. However, it is always best to consult with a healthcare professional.


TikTok Buzz: Magnesium Glycinate for Sleep and Anxiety


Magnesium glycinate has gained popularity on TikTok, with many users claiming it improves sleep and reduces anxiety. While some scientific evidence supports these claims, individual results may vary. Magnesium glycinate may be beneficial for those with muscle tension, magnesium deficiency, or sleep disturbances.


Are Magnesium Glycinate Supplements Worth It?


Magnesium glycinate supplements are widely available and can be purchased online or at health food stores. Whether they are worth the investment depends on your health needs and goals. If you’re magnesium deficient or looking to improve sleep and reduce anxiety, magnesium glycinate could be a worthwhile supplement. However, if you maintain a balanced diet and have no specific health concerns, you may not need it.


Conclusion


Magnesium is an essential mineral for overall health and well-being, and magnesium glycinate offers several benefits, including better sleep, reduced anxiety, and improved digestion. While it’s not a miracle cure, it can be a valuable supplement for those with a magnesium deficiency or those looking to enhance their overall health. Before adding magnesium glycinate to your routine, consult a healthcare professional to ensure it's safe and appropriate for you.


Green As Nature sells Magnesium Glycinate as well as a special formulation of Magnesium Glycinate and Ashwagandha Extract, for more information visit www.greenasnature.com


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